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KMID : 0043320070300091155
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Archives of Pharmacal Research
2007 Volume.30 No. 9 p.1155 ~ p.1161
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Effects of Vehicles and Enhancers on Transdermal Delivery of Clebopride
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Rhee Yun-Seok
Huh Jai-Yong
Park Chun-Woong
Nam Tae-Young
Yoon Koog-Ryul
Chi Sang-Cheol
Park Eun-Seok
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Abstract
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The effects of vehicles and penetration enhancers on the skin permeation of clebopride were evaluated using Franz type diffusion cells fitted with excised rat dorsal skins. The binary vehicle system, diethylene glycol monoethyl ether/isopropyl myristate (40/60, w/w), significantly enhanced the skin permeation rate of clebopride. The skin permeation enhancers, oleic acid and ethanol when used in the binary vehicle system, resulted in relatively high clebopride skin permeation rates. A gel formulation consisting of 1.5% (w/w) clebopride, 5% (w/w) oleic acid, and 7% (w/w) gelling agent with the binary vehicle system resulted in a permeation rate of 28.90 킽/cm2/h. Overall, these results highlight the potential of clebopride formulation for the transdermal route.
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KEYWORD
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Clebopride, Skin permeation, Vehicle, Enhancer, Binary vehicle system
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